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Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells

Chromosome alignment to the spindle equator is a hallmark of mitosis thought to promote chromosome segregation fidelity in metazoans. Yet chromosome alignment is only indirectly supervised by the spindle assembly checkpoint (SAC) as a byproduct of chromosome bi-orientation, and the consequences of d...

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Detalles Bibliográficos
Autores principales: Gomes, Ana Margarida, Orr, Bernardo, Novais-Cruz, Marco, De Sousa, Filipe, Macário-Monteiro, Joana, Lemos, Carolina, Ferrás, Cristina, Maiato, Helder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559752/
https://www.ncbi.nlm.nih.gov/pubmed/36057259
http://dx.doi.org/10.1016/j.cub.2022.08.026