Cargando…
Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells
Chromosome alignment to the spindle equator is a hallmark of mitosis thought to promote chromosome segregation fidelity in metazoans. Yet chromosome alignment is only indirectly supervised by the spindle assembly checkpoint (SAC) as a byproduct of chromosome bi-orientation, and the consequences of d...
Autores principales: | Gomes, Ana Margarida, Orr, Bernardo, Novais-Cruz, Marco, De Sousa, Filipe, Macário-Monteiro, Joana, Lemos, Carolina, Ferrás, Cristina, Maiato, Helder |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559752/ https://www.ncbi.nlm.nih.gov/pubmed/36057259 http://dx.doi.org/10.1016/j.cub.2022.08.026 |
Ejemplares similares
-
An anaphase surveillance mechanism prevents micronuclei formation from frequent chromosome segregation errors
por: Orr, Bernardo, et al.
Publicado: (2021) -
Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis
por: Schweizer, Nina, et al.
Publicado: (2013) -
Mitotic DNA damage promotes chromokinesin-mediated missegregation of polar chromosomes in cancer cells
por: Novais-Cruz, Marco, et al.
Publicado: (2023) -
Mechanisms of Chromosome Congression during Mitosis
por: Maiato, Helder, et al.
Publicado: (2017) -
No chromosome left behind: The importance of metaphase alignment for mitotic fidelity
por: Orr, Bernardo, et al.
Publicado: (2019)