Cargando…

Successful Proof-of-Concept for Topical Delivery of Novel Peptide ALM201 with Potential Usefulness for Treating Neovascular Eye Disorders

PURPOSE: To evaluate the therapeutic benefit of a novel peptide, ALM201, in ocular pathologic vascularization. DESIGN: Experimental study in mouse, rat, and rabbit animal models. PARTICIPANTS: Ten-week-old Lister Hooded male rats, 8-week-old Brown Norway male rats, 9-day-old C57BL/6J mice, and 12-mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Obasanmi, Gideon, Nesbit, M. Andrew, Cobice, Diego, Mackay, Logan, McGimpsey, Stuart, Wappett, Mark, Cranston, Aaron N., Moore, Tara C.B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560569/ https://www.ncbi.nlm.nih.gov/pubmed/36249680 http://dx.doi.org/10.1016/j.xops.2022.100150

Ejemplares similares

FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer
por: Annett, Stephanie, et al.
Publicado: (2019)

In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201
por: Osytek, Katarzyna M., et al.
Publicado: (2021)

Not Alms, but a Friend
Publicado: (1887)

A first-in-human Phase I dose-escalation trial of the novel therapeutic peptide, ALM201, demonstrates a favourable safety profile in unselected patients with ovarian cancer and other advanced solid tumours
por: El Helali, Aya, et al.
Publicado: (2022)

Baltimore Alms-House Infirmary
Publicado: (1830)

A farewell to alms : a brief economic history of the world /
por: Clark, Gregory, 1957-
Publicado: (2007)

US201 Study: A Phase 2, Randomized Proof-of-Concept Trial of Favipiravir for the Treatment of COVID-19
por: Finberg, Robert W, et al.
Publicado: (2021)

Neovascularization of the optic disc and peripheral retinal ischemia in a child with a novel variant in ALMS1 (Alström syndrome)
por: Chang, Melinda Y., et al.
Publicado: (2022)

Infective endocarditis due to Gemella morbillorum complicating hypertrophic obstructive cardiomyopathy.
por: Kerr, J. R., et al.
Publicado: (1994)

Alme de mi alma : el México de los extranjeros
por: Miller, Carol
Publicado: (2011)

Continuous delivery with Visual Studio ALM 2015
por: Olausson , Mathias, et al.
Publicado: (2015)

Agile ALM: lightweight tools and agile strategies
por: Hüttermann, Michael
Publicado: (2012)

Centriolar Association of ALMS1 and Likely Centrosomal Functions of the ALMS Motif–containing Proteins C10orf90 and KIAA1731
por: Knorz, Victoria J., et al.
Publicado: (2010)

Mechanisms Underlying the Antiarrhythmic Action of Compound ALM-802
por: Tsorin, I. B., et al.
Publicado: (2023)

Response to Imatinib therapy is inferior for e13a2 BCR-ABL1 transcript type in comparison to e14a2 transcript type in chronic myeloid leukaemia
por: Greenfield, Graeme, et al.
Publicado: (2019)

Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide
por: Schiroli, Davide, et al.
Publicado: (2019)

Outcome of primary rhegmatogenous retinal detachment surgery in a tertiary referral centre in Northern Ireland – A regional study
por: Mikhail, Michael A, et al.
Publicado: (2017)

Different evolutionary trends form the twilight zone of the bacterial pan-genome
por: Horesh, Gal, et al.
Publicado: (2021)

Spatial localization of β-unsaturated aldehyde markers in murine diabetic kidney tissue by mass spectrometry imaging
por: Harkin, Carla, et al.
Publicado: (2022)

Novel ALMS1 mutations in Chinese patients with Alström syndrome
por: Liang, Xiaofang, et al.
Publicado: (2013)

Prevalent ALMS1 Pathogenic Variants in Spanish Alström Patients
por: Bea-Mascato, Brais, et al.
Publicado: (2021)

Novel Mutations of the ALMS1 Gene in Patients with Alström Syndrome
por: Wang, Chunmei, et al.
Publicado: (2021)

Influence of race/ethnicity on response to lupus nephritis treatment: the ALMS study
por: Isenberg, David, et al.
Publicado: (2010)

ALMS1 Regulates TGF-β Signaling and Morphology of Primary Cilia
por: Álvarez-Satta, María, et al.
Publicado: (2021)

The incidence and rate of rhegmatogenous retinal detachment seven years after cataract surgery in patients with high myopia
por: Williams, Michael A, et al.
Publicado: (2009)

The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components
por: Salas-Pino, Silvia, et al.
Publicado: (2017)

ALM Therapy Promotes Functional and Histologic Regeneration of Traumatized Peripheral Skeletal Muscle
por: Hoeger, Nina Sarah, et al.
Publicado: (2023)

Memorandum 201
por: CERN. Geneva. Proton Synchrotron and Synchrocyclotron Committee
Publicado: (1984)

Design Considerations for Intratracheal Delivery Devices to Achieve Proof-of-Concept Dry Powder Biopharmaceutical Delivery in Mice
por: Manser, Myla, et al.
Publicado: (2023)

Sustained software development, not number of citations or journal choice, is indicative of accurate bioinformatic software
por: Gardner, Paul P., et al.
Publicado: (2022)

A Role for Alström Syndrome Protein, Alms1, in Kidney Ciliogenesis and Cellular Quiescence
por: Li, Guochun, et al.
Publicado: (2007)

Alternative Perspectives on Impact: The Potential of ALMs and Altmetrics to Inform Funders about Research Impact
por: Dinsmore, Adam, et al.
Publicado: (2014)

Characterization of Alstrom Syndrome 1 (ALMS1) Transcript Variants in Hodgkin Lymphoma Cells
por: Braune, Katarina, et al.
Publicado: (2017)

ALMS1 and Alström syndrome: a recessive form of metabolic, neurosensory and cardiac deficits
por: Hearn, Tom
Publicado: (2018)

New pathogenic variants of ALMS1 gene in two Chinese families with Alström Syndrome
por: Cheng, Wan-Yu, et al.
Publicado: (2022)

On‐tissue chemical derivatization in mass spectrometry imaging
por: Harkin, Carla, et al.
Publicado: (2021)

The Versatile Transceiver Proof of Concept
por: Troska, J, et al.
Publicado: (2009)

Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline
por: Goktas, Sertan, et al.
Publicado: (2014)

Topical Timolol Inhibits Corneal Neovascularization in Rabbits
por: KASIRI, Ali, et al.
Publicado: (2017)

Antioxidant Phytochemicals as Potential Therapy for Diabetic Complications
por: Akpoveso, Oke-Oghene Philomena, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_k1rf9jjgjg1hfce52esvkore1p