Revisiting Leishmania GP63 host cell targets reveals a limited spectrum of substrates

Colonization of host phagocytic cells by Leishmania metacyclic promastigotes involves several parasite effectors, including the zinc-dependent metalloprotease GP63. The major mode of action of this virulence factor entails the cleavage/degradation of host cell proteins. Given the potent proteolytic...

Descripción completa

Detalles Bibliográficos
Autores principales: Guay-Vincent, Marie-Michèle, Matte, Christine, Berthiaume, Anne-Marie, Olivier, Martin, Jaramillo, Maritza, Descoteaux, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560592/
https://www.ncbi.nlm.nih.gov/pubmed/36191034
http://dx.doi.org/10.1371/journal.ppat.1010640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560592/
https://www.ncbi.nlm.nih.gov/pubmed/36191034
http://dx.doi.org/10.1371/journal.ppat.1010640

Ejemplares similares