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Revisiting Leishmania GP63 host cell targets reveals a limited spectrum of substrates

Colonization of host phagocytic cells by Leishmania metacyclic promastigotes involves several parasite effectors, including the zinc-dependent metalloprotease GP63. The major mode of action of this virulence factor entails the cleavage/degradation of host cell proteins. Given the potent proteolytic...

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Detalles Bibliográficos
Autores principales:	Guay-Vincent, Marie-Michèle, Matte, Christine, Berthiaume, Anne-Marie, Olivier, Martin, Jaramillo, Maritza, Descoteaux, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560592/ https://www.ncbi.nlm.nih.gov/pubmed/36191034 http://dx.doi.org/10.1371/journal.ppat.1010640

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