[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes

Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable drug discovery. Herein we disclose [2]-ladderanes as a class of meta-substituted aromatic ring isosteres and rigidified cyclohexanes. A straightforward synthesis of the building blocks is presented along wit...

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Detalles Bibliográficos
Autores principales: Epplin, Rachel C., Paul, Shashwati, Herter, Loïc, Salome, Christophe, Hancock, Erin N., Larrow, Jay F., Baum, Erich W., Dunstan, David R., Ginsburg-Moraff, Carol, Fessard, Thomas C., Brown, M. Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561113/
https://www.ncbi.nlm.nih.gov/pubmed/36229621
http://dx.doi.org/10.1038/s41467-022-33827-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561113/
https://www.ncbi.nlm.nih.gov/pubmed/36229621
http://dx.doi.org/10.1038/s41467-022-33827-3

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