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[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes
Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable drug discovery. Herein we disclose [2]-ladderanes as a class of meta-substituted aromatic ring isosteres and rigidified cyclohexanes. A straightforward synthesis of the building blocks is presented along wit...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561113/ https://www.ncbi.nlm.nih.gov/pubmed/36229621 http://dx.doi.org/10.1038/s41467-022-33827-3 |