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Atovaquone for treatment of COVID-19: A prospective randomized, double-blind, placebo-controlled clinical trial
Background: An in silico screen was performed to identify FDA approved drugs that inhibit SARS-CoV-2 main protease (M(pro)), followed by in vitro viral replication assays, and in vivo pharmacokinetic studies in mice. These studies identified atovaquone as a promising candidate for inhibiting viral r...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561237/ https://www.ncbi.nlm.nih.gov/pubmed/36249792 http://dx.doi.org/10.3389/fphar.2022.1020123 |