Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives

The short oligodeoxynucleotide (ODN) probes are suitable for good discrimination of point mutations. However, the probes suffer from low melting temperatures. In this work, the strategy of using acridine-4-carboxamide intercalators to improve thermal stabilisation is investigated. The study of large...

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Detalles Bibliográficos
Autores principales: Kostelansky, Filip, Miletin, Miroslav, Havlinova, Zuzana, Szotakova, Barbora, Libra, Antonin, Kucera, Radim, Novakova, Veronika, Zimcik, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561273/
https://www.ncbi.nlm.nih.gov/pubmed/36156152
http://dx.doi.org/10.1093/nar/gkac777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561273/
https://www.ncbi.nlm.nih.gov/pubmed/36156152
http://dx.doi.org/10.1093/nar/gkac777

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