Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model

Covalent DNA interstrand crosslinks are toxic DNA damage lesions that block the replication machinery that can cause a genomic instability. Ubiquitous abasic DNA sites are particularly susceptible to spontaneous cross-linking with a base from the opposite DNA strand. Detection of a crosslink induces...

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Detalles Bibliográficos
Autores principales: Huskova, Andrea, Dinesh, Dhurvas Chandrasekaran, Srb, Pavel, Boura, Evzen, Veverka, Vaclav, Silhan, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561275/
https://www.ncbi.nlm.nih.gov/pubmed/36155818
http://dx.doi.org/10.1093/nar/gkac793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561275/
https://www.ncbi.nlm.nih.gov/pubmed/36155818
http://dx.doi.org/10.1093/nar/gkac793

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