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Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model
Covalent DNA interstrand crosslinks are toxic DNA damage lesions that block the replication machinery that can cause a genomic instability. Ubiquitous abasic DNA sites are particularly susceptible to spontaneous cross-linking with a base from the opposite DNA strand. Detection of a crosslink induces...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561275/ https://www.ncbi.nlm.nih.gov/pubmed/36155818 http://dx.doi.org/10.1093/nar/gkac793 |