Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA

The RNA-binding protein tristetraprolin (TTP) is a potent activator of mRNA decay, specifically for transcripts bearing AU-rich elements (AREs) in their 3′-untranslated regions. TTP functions as a mediator for mRNA decay by interacting with the decay machinery and recruiting it to the target ARE-mRN...

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Detalles Bibliográficos
Autores principales: Maciej, Vincent D, Mateva, Nevena, Schwarz, Juliane, Dittmers, Theresa, Mallick, Megha, Urlaub, Henning, Chakrabarti, Sutapa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561381/
https://www.ncbi.nlm.nih.gov/pubmed/36130271
http://dx.doi.org/10.1093/nar/gkac797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561381/
https://www.ncbi.nlm.nih.gov/pubmed/36130271
http://dx.doi.org/10.1093/nar/gkac797

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