Blocking domain 6 of high molecular weight kininogen to understand intrinsic clotting mechanisms

BACKGROUND: The contact system is initiated by factor (F) XII activation and the assembly of high molecular weight kininogen (HK) with either FXI or prekallikrein (PK) on a negatively charged surface. Overactivation of this system contributes to thrombosis and inflammation in numerous diseases. To d...

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Detalles Bibliográficos
Autores principales: Singh, Pradeep K., Chen, Zu‐Lin, Horn, Katharina, Norris, Erin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561425/
https://www.ncbi.nlm.nih.gov/pubmed/36254255
http://dx.doi.org/10.1002/rth2.12815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561425/
https://www.ncbi.nlm.nih.gov/pubmed/36254255
http://dx.doi.org/10.1002/rth2.12815

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