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Blocking domain 6 of high molecular weight kininogen to understand intrinsic clotting mechanisms
BACKGROUND: The contact system is initiated by factor (F) XII activation and the assembly of high molecular weight kininogen (HK) with either FXI or prekallikrein (PK) on a negatively charged surface. Overactivation of this system contributes to thrombosis and inflammation in numerous diseases. To d...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561425/ https://www.ncbi.nlm.nih.gov/pubmed/36254255 http://dx.doi.org/10.1002/rth2.12815 |