Loss of stability and unfolding cooperativity in hPGK1 upon gradual structural perturbation of its N-terminal domain hydrophobic core

Phosphoglycerate kinase has been a model for the stability, folding cooperativity and catalysis of a two-domain protein. The human isoform 1 (hPGK1) is associated with cancer development and rare genetic diseases that affect several of its features. To investigate how mutations affect hPGK1 folding...

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Detalles Bibliográficos
Autores principales: Pacheco-García, Juan Luis, Loginov, Dmitry S., Naganathan, Athi N., Vankova, Pavla, Cano-Muñoz, Mario, Man, Petr, Pey, Angel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561527/
https://www.ncbi.nlm.nih.gov/pubmed/36229482
http://dx.doi.org/10.1038/s41598-022-22088-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561527/
https://www.ncbi.nlm.nih.gov/pubmed/36229482
http://dx.doi.org/10.1038/s41598-022-22088-1

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