Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson’s disease

We have developed an efficient approach to generate functional induced dopaminergic (DA) neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of patient fibroblasts with idiopathic Parkinson’s disease (PD), we could specifically detect disease-relevant pathology in the...

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Detalles Bibliográficos
Autores principales: Drouin-Ouellet, Janelle, Legault, Emilie M., Nilsson, Fredrik, Pircs, Karolina, Bouquety, Julie, Petit, Florence, Shrigley, Shelby, Birtele, Marcella, Pereira, Maria, Storm, Petter, Sharma, Yogita, Bruzelius, Andreas, Vuono, Romina, Kele, Malin, Stoker, Thomas B., Ottosson, Daniella Rylander, Falk, Anna, Jakobsson, Johan, Barker, Roger A., Parmar, Malin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561608/
https://www.ncbi.nlm.nih.gov/pubmed/36150382
http://dx.doi.org/10.1016/j.stemcr.2022.08.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561608/
https://www.ncbi.nlm.nih.gov/pubmed/36150382
http://dx.doi.org/10.1016/j.stemcr.2022.08.010

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