Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons

Mitochondria are essential organelle required for neuronal homeostasis. Mitochondria supply ATP and buffer calcium at synaptic terminals. However, the complex structural geometry of neurons poses a unique challenge in transporting mitochondria to synaptic terminals. Kinesin motors supply mitochondri...

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Detalles Bibliográficos
Autores principales: Sabui, Anusruti, Biswas, Mitali, Somvanshi, Pramod Rajaram, Kandagiri, Preethi, Gorla, Madhavi, Mohammed, Fareed, Tammineni, Prasad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561864/
https://www.ncbi.nlm.nih.gov/pubmed/36245925
http://dx.doi.org/10.3389/fnmol.2022.927195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561864/
https://www.ncbi.nlm.nih.gov/pubmed/36245925
http://dx.doi.org/10.3389/fnmol.2022.927195

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