Investigating Two Modes of Cancer-Associated Antigen Heterogeneity in an Agent-Based Model of Chimeric Antigen Receptor T-Cell Therapy

SIMPLE SUMMARY: Chimeric antigen receptor (CAR) T-cell therapy has shown much promise in liquid tumors but often fails in solid tumors. This work uses a computational model to examine under what conditions this therapy might fail or be successful. The model includes interactions between cancer cells...

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Detalles Bibliográficos
Autores principales: Giorgadze, Tina, Fischel, Henning, Tessier, Ansel, Norton, Kerri-Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561977/
https://www.ncbi.nlm.nih.gov/pubmed/36231127
http://dx.doi.org/10.3390/cells11193165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561977/
https://www.ncbi.nlm.nih.gov/pubmed/36231127
http://dx.doi.org/10.3390/cells11193165

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