Novel Methods of Targeting IL-1 Signalling for the Treatment of Breast Cancer Bone Metastasis

SIMPLE SUMMARY: The pro-inflammatory cytokine, IL1β, plays a pivotal role in breast cancer bone metastasis. Inhibiting IL-1 signalling with the IL1β specific antibody, Canakinumab, or the IL1R1 antagonist Anakinra almost eliminates bone metastases but has adverse effects on tumours growing outside o...

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Detalles Bibliográficos
Autores principales: Zhou, Jiabao, Down, Jennifer M., George, Christopher N., Murphy, Jessica, Lefley, Diane V., Tulotta, Claudia, Alsharif, Marwa A., Leach, Michael, Ottewell, Penelope D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561984/
https://www.ncbi.nlm.nih.gov/pubmed/36230739
http://dx.doi.org/10.3390/cancers14194816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561984/
https://www.ncbi.nlm.nih.gov/pubmed/36230739
http://dx.doi.org/10.3390/cancers14194816

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