Cargando…

Novel Methods of Targeting IL-1 Signalling for the Treatment of Breast Cancer Bone Metastasis

SIMPLE SUMMARY: The pro-inflammatory cytokine, IL1β, plays a pivotal role in breast cancer bone metastasis. Inhibiting IL-1 signalling with the IL1β specific antibody, Canakinumab, or the IL1R1 antagonist Anakinra almost eliminates bone metastases but has adverse effects on tumours growing outside o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Jiabao, Down, Jennifer M., George, Christopher N., Murphy, Jessica, Lefley, Diane V., Tulotta, Claudia, Alsharif, Marwa A., Leach, Michael, Ottewell, Penelope D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561984/ https://www.ncbi.nlm.nih.gov/pubmed/36230739 http://dx.doi.org/10.3390/cancers14194816

Ejemplares similares

The role of IL-1B in breast cancer bone metastasis
por: Tulotta, Claudia, et al.
Publicado: (2018)

IL-1 drives breast cancer growth and bone metastasis in vivo
por: Holen, Ingunn, et al.
Publicado: (2016)

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts
por: Lefley, Diane, et al.
Publicado: (2019)

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
por: Eyre, Rachel, et al.
Publicado: (2019)

IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer
por: Tulotta, Claudia, et al.
Publicado: (2021)

The role of osteoblasts in bone metastasis
por: Ottewell, Penelope D
Publicado: (2016)

Pretreatment of breast cancer cells with doxorubicin facilitates the subsequent uptake of zoledronic acid
por: Lefley, DV, et al.
Publicado: (2008)

Mechanisms of apoptosis and cell-cycle arrest in subcutaneous breast tumours treated sequentially with doxorubicin followed by zoledronic acid
por: Ottewell, PD, et al.
Publicado: (2008)

Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo
por: Holen, Ingunn, et al.
Publicado: (2012)

Erratum to: Loss of plakoglobin promotes cell-cell contact, increased invasion and breast cancer cell dissemination in vivo
por: Holen, Ingunn, et al.
Publicado: (2017)

Oestradiol Contributes to Differential Antitumour Effects of Adjuvant Zoledronic Acid Observed Between Pre- and Post-Menopausal Women
por: Canuas-Landero, Victor G., et al.
Publicado: (2021)

The bone metastasis niche in breast cancer-potential overlap with the haematopoietic stem cell niche in vivo
por: Allocca, Gloria, et al.
Publicado: (2019)

The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo
por: Saleh, Lubaid, et al.
Publicado: (2023)

CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment
por: Westbrook, Jules A., et al.
Publicado: (2016)

The differential anti-tumour effects of zoledronic acid in breast cancer – evidence for a role of the activin signaling pathway
por: Wilson, Caroline, et al.
Publicado: (2015)

Transcriptomic Profiling Reveals Novel Candidate Genes and Signalling Programs in Breast Cancer Quiescence and Dormancy †
por: Quayle, Lewis A., et al.
Publicado: (2021)

The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer
por: Wang, Ning, et al.
Publicado: (2015)

The IL‐1/IL‐1R axis induces greater fibroblast‐derived chemokine release in human papillomavirus‐negative compared to positive oropharyngeal cancer
por: Al‐Sahaf, Sarmad, et al.
Publicado: (2018)

Bone-Targeted Agents in Breast Cancer: Do We Now Have All the Answers?
por: Ottewell, Penny, et al.
Publicado: (2019)

Increased Abundance of Tumour-Associated Neutrophils in HPV-Negative Compared to HPV-Positive Oropharyngeal Squamous Cell Carcinoma Is Mediated by IL-1R Signalling
por: Al-Sahaf, Sarmad, et al.
Publicado: (2021)

Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention
por: Quayle, Lewis A., et al.
Publicado: (2018)

The Signaling Pathways Associated With Breast Cancer Bone Metastasis
por: Song, Xuelian, et al.
Publicado: (2022)

Oestrogen and zoledronic acid driven changes to the bone and immune environments: Potential mechanisms underlying the differential anti-tumour effects of zoledronic acid in pre- and post-menopausal conditions
por: George, Christopher N., et al.
Publicado: (2020)

Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model
por: Tulotta, Claudia, et al.
Publicado: (2016)

IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment
por: Manore, Sara G., et al.
Publicado: (2022)

The kinetochore protein Cenp-F is a potential novel target for zoledronic acid in breast cancer cells
por: Brown, Hannah K, et al.
Publicado: (2011)

TGF-β Signaling in Breast Cancer Cell Invasion and Bone Metastasis
por: Drabsch, Yvette, et al.
Publicado: (2011)

The relationship between the Hippo signaling pathway and bone metastasis of breast cancer
por: Han, Qinyu, et al.
Publicado: (2023)

MiR-662 is associated with metastatic relapse in early-stage breast cancer and promotes metastasis by stimulating cancer cell stemness
por: Puppo, Margherita, et al.
Publicado: (2023)

Osteoblast-Derived Paracrine and Juxtacrine Signals Protect Disseminated Breast Cancer Cells from Stress
por: Hughes, Russell, et al.
Publicado: (2021)

IL-25 blockade inhibits metastasis in breast cancer
por: Jiang, Zhujun, et al.
Publicado: (2016)

IL-11 is essential in promoting osteolysis in breast cancer bone metastasis via RANKL-independent activation of osteoclastogenesis
por: Liang, Mengmeng, et al.
Publicado: (2019)

Osteolytic effects of tumoral estrogen signaling in an estrogen receptor-positive breast cancer bone metastasis model
por: Cheng, Julia N., et al.
Publicado: (2021)

Breast cancer metastasis to the bone: mechanisms of bone loss
por: Chen, Yu-Chi, et al.
Publicado: (2010)

Bone Targeted Therapies for Bone Metastasis in Breast Cancer
por: Razaq, Wajeeha
Publicado: (2013)

Wnt Signaling in the Development of Bone Metastasis
por: Ben-Ghedalia-Peled, Noa, et al.
Publicado: (2022)

Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies
por: Tawara, Ken, et al.
Publicado: (2011)

IL-6 variant is associated with metastasis in breast cancer patients
por: Abana, Chike O., et al.
Publicado: (2017)

Bone metastasis-related signaling pathways in breast cancers stratified by estrogen receptor status
por: Hayashi, Naoki, et al.
Publicado: (2017)

Parathyroid hormone 1 receptor signaling mediates breast cancer metastasis to bone in mice
por: Swami, Srilatha, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_q9o40h2msfa9jb8dh7k1lb4vjp