Bis(chloroacetamidino)-Derived Heteroarene-Fused Anthraquinones Bind to and Cause Proteasomal Degradation of tNOX, Leading to c-Flip Downregulation and Apoptosis in Oral Cancer Cells

SIMPLE SUMMARY: New-generation anthraquinone derivatives attached with different heterocycles and bearing chloroacetamidines in the side chains have been synthesized to reduce side effects and drug resistance. In this study, we identified the cellular target of the studied compounds through ligand b...

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Detalles Bibliográficos
Autores principales: Chang, Jeng Shiun, Chen, Chien-Yu, Tikhomirov, Alexander S., Islam, Atikul, Liang, Ru-Hao, Weng, Chia-Wei, Wu, Wei-Hou, Shchekotikhin, Andrey E., Chueh, Pin Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562014/
https://www.ncbi.nlm.nih.gov/pubmed/36230644
http://dx.doi.org/10.3390/cancers14194719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562014/
https://www.ncbi.nlm.nih.gov/pubmed/36230644
http://dx.doi.org/10.3390/cancers14194719

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