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Innovative Application of Metabolomics on Bioactive Ingredients of Foods

Metabolomics, as a new omics technology, has been widely accepted by researchers and has shown great potential in the field of nutrition and health in recent years. This review briefly introduces the process of metabolomics analysis, including sample preparation and extraction, derivatization, separ...

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Detalles Bibliográficos
Autores principales: Hu, Sumei, Liu, Caiyu, Liu, Xinqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562173/
https://www.ncbi.nlm.nih.gov/pubmed/36230049
http://dx.doi.org/10.3390/foods11192974
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author Hu, Sumei
Liu, Caiyu
Liu, Xinqi
author_facet Hu, Sumei
Liu, Caiyu
Liu, Xinqi
author_sort Hu, Sumei
collection PubMed
description Metabolomics, as a new omics technology, has been widely accepted by researchers and has shown great potential in the field of nutrition and health in recent years. This review briefly introduces the process of metabolomics analysis, including sample preparation and extraction, derivatization, separation and detection, and data processing. This paper focuses on the application of metabolomics in food-derived bioactive ingredients. For example, metabolomics techniques are used to analyze metabolites in food to find bioactive substances or new metabolites in food materials. Moreover, bioactive substances have been tested in vitro and in vivo, as well as in humans, to investigate the changes of metabolites and the underlying metabolic pathways, among which metabolomics is used to find potential biomarkers and targets. Metabolomics provides a new approach for the prevention and regulation of chronic diseases and the study of the underlying mechanisms. It also provides strong support for the development of functional food or drugs. Although metabolomics has some limitations such as low sensitivity, poor repeatability, and limited detection range, it is developing rapidly in general, and also in the field of nutrition and health. At the end of this paper, we put forward our own insights on the development prospects of metabolomics in the application of bioactive ingredients in food.
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spelling pubmed-95621732022-10-15 Innovative Application of Metabolomics on Bioactive Ingredients of Foods Hu, Sumei Liu, Caiyu Liu, Xinqi Foods Review Metabolomics, as a new omics technology, has been widely accepted by researchers and has shown great potential in the field of nutrition and health in recent years. This review briefly introduces the process of metabolomics analysis, including sample preparation and extraction, derivatization, separation and detection, and data processing. This paper focuses on the application of metabolomics in food-derived bioactive ingredients. For example, metabolomics techniques are used to analyze metabolites in food to find bioactive substances or new metabolites in food materials. Moreover, bioactive substances have been tested in vitro and in vivo, as well as in humans, to investigate the changes of metabolites and the underlying metabolic pathways, among which metabolomics is used to find potential biomarkers and targets. Metabolomics provides a new approach for the prevention and regulation of chronic diseases and the study of the underlying mechanisms. It also provides strong support for the development of functional food or drugs. Although metabolomics has some limitations such as low sensitivity, poor repeatability, and limited detection range, it is developing rapidly in general, and also in the field of nutrition and health. At the end of this paper, we put forward our own insights on the development prospects of metabolomics in the application of bioactive ingredients in food. MDPI 2022-09-23 /pmc/articles/PMC9562173/ /pubmed/36230049 http://dx.doi.org/10.3390/foods11192974 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hu, Sumei
Liu, Caiyu
Liu, Xinqi
Innovative Application of Metabolomics on Bioactive Ingredients of Foods
title Innovative Application of Metabolomics on Bioactive Ingredients of Foods
title_full Innovative Application of Metabolomics on Bioactive Ingredients of Foods
title_fullStr Innovative Application of Metabolomics on Bioactive Ingredients of Foods
title_full_unstemmed Innovative Application of Metabolomics on Bioactive Ingredients of Foods
title_short Innovative Application of Metabolomics on Bioactive Ingredients of Foods
title_sort innovative application of metabolomics on bioactive ingredients of foods
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562173/
https://www.ncbi.nlm.nih.gov/pubmed/36230049
http://dx.doi.org/10.3390/foods11192974
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