Cargando…

Spatial Profiling of the Prostate Cancer Tumor Microenvironment Reveals Multiple Differences in Gene Expression and Correlation with Recurrence Risk

SIMPLE SUMMARY: In prostate cancer (PCa), the tumor microenvironment plays a crucial role in both the development and progression of the disease. We used Digital Spatial Profiling multiplex technology to assess the expression of 58 protein and 1825 RNA transcripts in traditionally challenging sample...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Vinay, Randhawa, Pavneet, Bilodeau, Robert, Mercola, Dan, McClelland, Michael, Agrawal, Anshu, Nguyen, James, Castro, Patricia, Ittmann, Michael M., Rahmatpanah, Farah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562240/ https://www.ncbi.nlm.nih.gov/pubmed/36230846 http://dx.doi.org/10.3390/cancers14194923

Ejemplares similares

RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White Americans
por: Rahmatpanah, Farah, et al.
Publicado: (2021)

Expression of Endogenous Retroviral RNA in Prostate Tumors has Prognostic Value and Shows Differences among Americans of African Versus European/Middle Eastern Ancestry
por: Kumar, Vinay, et al.
Publicado: (2021)

Transcriptome Analysis of Ovarian and Uterine Clear Cell Malignancies
por: Alldredge, Jill, et al.
Publicado: (2020)

Role of the Adjacent Stroma Cells in Prostate Cancer Development and Progression: Synergy between TGF-β and IGF Signaling
por: Lee, Chung, et al.
Publicado: (2014)

An Accurate Prostate Cancer Prognosticator Using a Seven-Gene Signature Plus Gleason Score and Taking Cell Type Heterogeneity into Account
por: Chen, Xin, et al.
Publicado: (2012)

Airway epithelial cells prime plasmacytoid dendritic cells to respond to pathogens via secretion of growth factors
por: Rahmatpanah, Farah, et al.
Publicado: (2018)

Correction: Airway epithelial cells prime plasmacytoid dendritic cells to respond to pathogens via secretion of growth factors
por: Rahmatpanah, Farah, et al.
Publicado: (2019)

The identification of trans-associations between prostate cancer GWAS SNPs and RNA expression differences in tumor-adjacent stroma
por: Chen, Xin, et al.
Publicado: (2015)

Expression Changes in the Stroma of Prostate Cancer Predict Subsequent Relapse
por: Jia, Zhenyu, et al.
Publicado: (2012)

Correction: Expression Changes in the Stroma of Prostate Cancer Predict Subsequent Relapse
por: Jia, Zhenyu, et al.
Publicado: (2012)

TGF-β mediated DNA methylation in prostate cancer
por: Lee, Chung, et al.
Publicado: (2012)

A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors
por: Rahmatpanah, Farah B., et al.
Publicado: (2014)

Editorial: Therapeutic Opportunities and Innovative Biomarkers in Tumor Microenvironment
por: Xu, Kexin, et al.
Publicado: (2021)

Vitamin C Enhances Antiviral Functions of Lung Epithelial Cells
por: Teafatiller, Trevor, et al.
Publicado: (2021)

Overexpression of Periostin in Stroma Positively Associated with Aggressive Prostate Cancer
por: Tian, Yuan, et al.
Publicado: (2015)

Correction: Overexpression of Periostin in Stroma Positively Associated with Aggressive Prostate Cancer
por: Tian, Yuan, et al.
Publicado: (2015)

Six stroma-based RNA markers diagnostic for prostate cancer in European-Americans validated at the RNA and protein levels in patients in China
por: Zhu, Jianguo, et al.
Publicado: (2015)

Kallikrein gene family as biomarkers for recurrent prostate cancer
por: Busra Boyukozer, Fatma, et al.
Publicado: (2020)

Influence of the neural microenvironment on prostate cancer
por: Coarfa, Christian, et al.
Publicado: (2017)

Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip
por: Arora, Shilpi, et al.
Publicado: (2008)

Generalization Through the Recurrent Interaction of Episodic Memories: A Model of the Hippocampal System
por: Kumaran, Dharshan, et al.
Publicado: (2012)

Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors
por: Feng, Shu, et al.
Publicado: (2016)

Disparities in the Utilization of Radiation Therapy for Prostate Cancer in the United States: A Comprehensive Review
por: Gardner, Ulysses, et al.
Publicado: (2022)

Early Growth Response 3 (Egr3) Is Highly Over-Expressed in Non-Relapsing Prostate Cancer but Not in Relapsing Prostate Cancer
por: Pio, Rebecca, et al.
Publicado: (2013)

miR-1 and miR-133b Are Differentially Expressed in Patients with Recurrent Prostate Cancer
por: Karatas, Omer Faruk, et al.
Publicado: (2014)

Endogenous Retrovirus RNA Expression Differences between Race, Stage and HPV Status Offer Improved Prognostication among Women with Cervical Cancer
por: Alldredge, Jill, et al.
Publicado: (2023)

Generation of “Virtual” Control Groups for Single Arm Prostate Cancer Adjuvant Trials
por: Jia, Zhenyu, et al.
Publicado: (2014)

Comparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer
por: Creighton, Chad J., et al.
Publicado: (2023)

FGF23 promotes prostate cancer progression
por: Feng, Shu, et al.
Publicado: (2015)

Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks
por: Uttam, Shikhar, et al.
Publicado: (2020)

Frequent Heterogeneous Missense Mutations of GGAP2 in Prostate Cancer: Implications for Tumor Biology, Clonality and Mutation Analysis
por: Cai, Yi, et al.
Publicado: (2012)

The potential of tumour microenvironment markers to stratify the risk of recurrence in prostate cancer patients
por: Gevaert, Thomas, et al.
Publicado: (2020)

Detection of recurrent rearrangement breakpoints from copy number data
por: Ritz , Anna, et al.
Publicado: (2011)

Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer
por: Su, Qingtai, et al.
Publicado: (2016)

WebArray: an online platform for microarray data analysis
por: Xia, Xiaoqin, et al.
Publicado: (2005)

SAT-326 INPP4B Suppresses Prostate Inflammation And Protects Mice Fed With High-fat Diet From The Development Of Prostate Intraepithelial Neoplasia
por: Zhang, Manqi, et al.
Publicado: (2019)

Dramatic polarization in genitourinary expert opinions regarding the clinical utility of positron emission tomography (PET) imaging in prostate cancer
por: Sandler, Kiri A., et al.
Publicado: (2019)

Prostate Cancer Postoperative Nomogram Scores and Obesity
por: Major, Jacqueline M., et al.
Publicado: (2011)

Characterization of 7-Methylguanosine Identified Biochemical Recurrence and Tumor Immune Microenvironment in Prostate Cancer
por: Xin, Sheng, et al.
Publicado: (2022)

Adobe Illustrator CS5 one-on-one
por: McClelland, Deke
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2a5ffj2v2v84e2n112hsebab77