Cargando…

AI protein structure prediction-based modeling and mutagenesis of a protostome receptor and peptide ligands reveal key residues for their interaction

The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-coupled receptors, has been characterized in several species. Despite the progress, molecular mechanisms governing LK peptide–receptor interactions remain to be elucidated. Previously, we identified a precurso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Shi-Qi, Li, Ya-Dong, Chen, Ping, Zhang, Guo, Wang, Hui-Ying, Jiang, Hui-Min, Liu, Wei-Jia, Xu, Ju-Ping, Ding, Xue-Ying, Fu, Ping, Yu, Ke, Zhou, Hai-Bo, Checco, James W., Jing, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562341/ https://www.ncbi.nlm.nih.gov/pubmed/36049520 http://dx.doi.org/10.1016/j.jbc.2022.102440

Ejemplares similares

Characterization of an Aplysia vasotocin signaling system and actions of posttranslational modifications and individual residues of the ligand on receptor activity
por: Xu, Ju-Ping, et al.
Publicado: (2023)

Conservation, loss, and redeployment of Wnt ligands in protostomes: implications for understanding the evolution of segment formation
por: Janssen, Ralf, et al.
Publicado: (2010)

Massive expansion and functional divergence of innate immune genes in a protostome
por: Zhang, Linlin, et al.
Publicado: (2015)

Ciliary photoreceptors in the cerebral eyes of a protostome larva
por: Passamaneck, Yale J, et al.
Publicado: (2011)

Human Developmental Enhancers Conserved between Deuterostomes and Protostomes
por: Clarke, Shoa L., et al.
Publicado: (2012)

Coe Genes Are Expressed in Differentiating Neurons in the Central Nervous System of Protostomes
por: Demilly, Adrien, et al.
Publicado: (2011)

Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin
por: Martin, Eliza C., et al.
Publicado: (2020)

The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution
por: Döring, Clemens Christoph, et al.
Publicado: (2020)

The evolution of the metazoan Toll receptor family and its expression during protostome development
por: Orús-Alcalde, Andrea, et al.
Publicado: (2021)

Ancient Protostome Origin of Chemosensory Ionotropic Glutamate Receptors and the Evolution of Insect Taste and Olfaction
por: Croset, Vincent, et al.
Publicado: (2010)

Site-directed mutagenesis identified the key active site residues of alcohol acyltransferase PpAAT1 responsible for aroma biosynthesis in peach fruits
por: Song, Zhi-Zhong, et al.
Publicado: (2021)

Structure of a Thermobifida fusca lytic polysaccharide monooxygenase and mutagenesis of key residues
por: Kruer-Zerhusen, Nathan, et al.
Publicado: (2017)

Identification of three elevenin receptors and roles of elevenin disulfide bond and residues in receptor activation in Aplysia californica
por: Fu, Ping, et al.
Publicado: (2023)

The evolution of protostome GATA factors: Molecular phylogenetics, synteny, and intron/exon structure reveal orthologous relationships
por: Gillis, William Q, et al.
Publicado: (2008)

Domain-Dependent Evolution Explains Functional Homology of Protostome and Deuterostome Complement C3-Like Proteins
por: Peng, Maoxiao, et al.
Publicado: (2022)

ABS–Scan: In silico alanine scanning mutagenesis for binding site residues in protein–ligand complex
por: Anand, Praveen, et al.
Publicado: (2014)

Site-Directed Mutagenesis Study Revealed Three Important Residues in Hc-DAF-22, a Key Enzyme Regulating Diapause of Haemonchus contortus
por: Huang, Yan, et al.
Publicado: (2017)

Alanine Mutagenesis in the Complementarity Determining Region 3 of the MTB and HIV-1 Peptide-Bispecific T Cell Receptor Beta Chain Affects Ligand Recognition
por: Zhou, Chao-Ying, et al.
Publicado: (2017)

Specific retention of the protostome-specific PsGEF may parallel with the evolution of mushroom bodies in insect and lophotrochozoan brains
por: Higuchi, Nozomu, et al.
Publicado: (2009)

Insights into the Origin of Nematode Chemosensory GPCRs: Putative Orthologs of the Srw Family Are Found across Several Phyla of Protostomes
por: Krishnan, Arunkumar, et al.
Publicado: (2014)

Ancient Origins of RGK Protein Function: Modulation of Voltage-Gated Calcium Channels Preceded the Protostome and Deuterostome Split
por: Puhl, Henry L., et al.
Publicado: (2014)

Identification of an allatostatin C signaling system in mollusc Aplysia
por: Jiang, Hui-Min, et al.
Publicado: (2022)

Identification and Application of Two Promising Peptide Ligands for the Immunodetection of Imidacloprid Residue
por: You, Tianyang, et al.
Publicado: (2022)

Key Residue for Aggregation of Amyloid-β Peptides
por: Itoh, Satoru G., et al.
Publicado: (2022)

Potential high-frequency off-target mutagenesis induced by CRISPR/Cas9 in Arabidopsis and its prevention
por: Zhang, Qiang, et al.
Publicado: (2018)

Phylogenetic Analyses and Characterization of RNase X25 from Drosophila melanogaster Suggest a Conserved Housekeeping Role and Additional Functions for RNase T2 Enzymes in Protostomes
por: Ambrosio, Linda, et al.
Publicado: (2014)

Endogenous l- to d-amino acid residue isomerization modulates selectivity between distinct neuropeptide receptor family members
por: Yussif, Baba M., et al.
Publicado: (2023)

An Examination by Site-Directed Mutagenesis of Putative Key Residues in the Determination of Coenzyme Specificity in Clostridial NAD(+)-Dependent Glutamate Dehydrogenase
por: Griffin, Joanna, et al.
Publicado: (2011)

Iron-based magnetic superhalogens with pseudohalogens as ligands: An unbiased structure search
por: Ping Ding, Li, et al.
Publicado: (2017)

Peptide Toxins as Biothreats and the Potential for AI Systems to Enhance Biosecurity
por: Lee, Ying-Chiang J., et al.
Publicado: (2022)

Alanine Scanning Mutagenesis of the C-Terminal Cytosolic End of Gpm6a Identifies Key Residues Essential for the Formation of Filopodia
por: Rosas, Nicolás M., et al.
Publicado: (2018)

Saturation mutagenesis of selected residues of the α-peptide of the lantibiotic lacticin 3147 yields a derivative with enhanced antimicrobial activity
por: Field, Des, et al.
Publicado: (2013)

AI-deploying organizations are key to addressing ‘perfect storm’ of AI risks
por: Curtis, Caitlin, et al.
Publicado: (2022)

Site-directed mutagenesis identified the key active site residues of 2,3-oxidosqualene cyclase HcOSC6 responsible for cucurbitacins biosynthesis in Hemsleya chinensis
por: Li, Xia, et al.
Publicado: (2023)

Exogenous expression of an allatotropin-related peptide receptor increased the membrane excitability in Aplysia neurons
por: Zhang, Guo, et al.
Publicado: (2022)

Structure-based dynamic analysis of the glycine cleavage system suggests key residues for control of a key reaction step
por: Zhang, Han, et al.
Publicado: (2020)

An optimized TALEN application for mutagenesis and screening in Drosophila melanogaster
por: Lee, Han B, et al.
Publicado: (2015)

In silico Structure–Based Investigation of Key Residues of Insecticidal Activity of Sip1Aa Protein
por: Wang, Jing, et al.
Publicado: (2020)

Mutagenesis of N-terminal residues confer thermostability on a Penicillium janthinellum MA21601 xylanase
por: Xiong, Ke, et al.
Publicado: (2019)

Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development
por: Liu, Chia-Lin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_hrumln7gq58f0l99gp1acpkgeb