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Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer’s Disease and Related Dementias

Recent findings of diverse populations of prion-like conformers of misfolded tau protein expand the prion concept to Alzheimer’s disease (AD) and monogenic frontotemporal lobar degeneration (FTLD)-MAPT P301L, and suggest that distinct strains of misfolded proteins drive the phenotypes and progressio...

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Detalles Bibliográficos
Autores principales:	Hromadkova, Lenka, Siddiqi, Mohammad Khursheed, Liu, He, Safar, Jiri G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562632/ https://www.ncbi.nlm.nih.gov/pubmed/36230957 http://dx.doi.org/10.3390/cells11192997

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