TGF-β-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine

TGF-β signaling is necessary for CD8(+) T cell differentiation into tissue resident memory T cells (T(RM)). Although higher frequency of CD8(+) T(RM) cells in the tumor microenvironment is associated with better prognosis, TGF-β−blockade typically improves rather than worsens outcomes. Here we show...

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Detalles Bibliográficos
Autores principales: Li, Guo, Srinivasan, Saranya, Wang, Liwen, Ma, Chaoyu, Guo, Kai, Xiao, Wenhao, Liao, Wei, Mishra, Shruti, Zhang, Xin, Qiu, Yuanzheng, Lu, Qianjin, Liu, Yong, Zhang, Nu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562983/
https://www.ncbi.nlm.nih.gov/pubmed/36229613
http://dx.doi.org/10.1038/s41467-022-33768-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562983/
https://www.ncbi.nlm.nih.gov/pubmed/36229613
http://dx.doi.org/10.1038/s41467-022-33768-x

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