Manganese-driven CoQ deficiency

Overexposure to manganese disrupts cellular energy metabolism across species, but the molecular mechanism underlying manganese toxicity remains enigmatic. Here, we report that excess cellular manganese selectively disrupts coenzyme Q (CoQ) biosynthesis, resulting in failure of mitochondrial bioenerg...

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Detalles Bibliográficos
Autores principales: Diessl, Jutta, Berndtsson, Jens, Broeskamp, Filomena, Habernig, Lukas, Kohler, Verena, Vazquez-Calvo, Carmela, Nandy, Arpita, Peselj, Carlotta, Drobysheva, Sofia, Pelosi, Ludovic, Vögtle, F.-Nora, Pierrel, Fabien, Ott, Martin, Büttner, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563070/
https://www.ncbi.nlm.nih.gov/pubmed/36229432
http://dx.doi.org/10.1038/s41467-022-33641-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563070/
https://www.ncbi.nlm.nih.gov/pubmed/36229432
http://dx.doi.org/10.1038/s41467-022-33641-x

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