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TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
BACKGROUND: Microglia, the innate immune cells in the central nervous system, play an essential role in brain homeostasis, neuroinflammation and brain infections. Dysregulated microglia, on the other hand, are associated with neurodegenerative diseases, yet the mechanisms underlying pro-inflammatory...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563125/ https://www.ncbi.nlm.nih.gov/pubmed/36241997 http://dx.doi.org/10.1186/s12974-022-02619-3 |