Repeated inhibition of sigma-1 receptor suppresses GABA(A) receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors

Sigma-1 receptor (σ(1)R) downregulation in male mice is known to cause a depressive-like phenotype. The nucleus accumbens (NAc), a region associated with affective regulation, has high levels of σ(1)R. Here, we investigated the effect of repeated inhibition of σ(1)R in the NAc on depressive-like beh...

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Detalles Bibliográficos
Autores principales: Qin, Yaoyao, Xu, Weixing, Li, Kunpeng, Luo, Qi, Chen, Xi, Wang, Yue, Chen, Lei, Sha, Sha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563353/
https://www.ncbi.nlm.nih.gov/pubmed/36245919
http://dx.doi.org/10.3389/fnmol.2022.959224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563353/
https://www.ncbi.nlm.nih.gov/pubmed/36245919
http://dx.doi.org/10.3389/fnmol.2022.959224

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