Identification of Novel MET Exon 14 Skipping Variants in Non-Small Cell Lung Cancer Patients: A Prototype Workflow Involving in Silico Prediction and RT-PCR

HIGHLIGHTS: MET exon 14 skipping is an oncogenic targetable driver mutation in lung cancer. Two novel non-canonical splice site variants identified in MET genome. Predicted splicing strength using in silico splicing prediction tools. Tested routine cytological smear slides for RNA-based molecular di...

Descripción completa

Detalles Bibliográficos
Autores principales: Das, Riku, Jakubowski, Maureen A., Spildener, Jessica, Cheng, Yu-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563401/
https://www.ncbi.nlm.nih.gov/pubmed/36230737
http://dx.doi.org/10.3390/cancers14194814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563401/
https://www.ncbi.nlm.nih.gov/pubmed/36230737
http://dx.doi.org/10.3390/cancers14194814

Ejemplares similares