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Identification of Novel MET Exon 14 Skipping Variants in Non-Small Cell Lung Cancer Patients: A Prototype Workflow Involving in Silico Prediction and RT-PCR

HIGHLIGHTS: MET exon 14 skipping is an oncogenic targetable driver mutation in lung cancer. Two novel non-canonical splice site variants identified in MET genome. Predicted splicing strength using in silico splicing prediction tools. Tested routine cytological smear slides for RNA-based molecular di...

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Detalles Bibliográficos
Autores principales:	Das, Riku, Jakubowski, Maureen A., Spildener, Jessica, Cheng, Yu-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563401/ https://www.ncbi.nlm.nih.gov/pubmed/36230737 http://dx.doi.org/10.3390/cancers14194814

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