Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Na(v)1.5 downregulation and ventricular arrhythmias

BACKGROUND: Abnormal myocardial Na(v)1.5 expression and function cause lethal ventricular arrhythmias during myocardial ischemia–reperfusion (I/R). Protein inhibitor of activated STAT Y (PIASy)-mediated caveolin-3 (Cav-3) SUMO modification affects Cav-3 binding to the voltage-gated sodium channel 1....

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Detalles Bibliográficos
Autores principales: Hu, Chen-Chen, Wei, Xin, Liu, Jin-Min, Han, Lin-Lin, Xia, Cheng-Kun, Wu, Jing, You, Tao, Zhu, A.-Fang, Yao, Shang-Long, Yuan, Shi-Ying, Xu, Hao-Dong, Xia, Zheng-Yuan, Wang, Ting-Ting, Mao, Wei-Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563440/
https://www.ncbi.nlm.nih.gov/pubmed/36229865
http://dx.doi.org/10.1186/s40779-022-00415-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563440/
https://www.ncbi.nlm.nih.gov/pubmed/36229865
http://dx.doi.org/10.1186/s40779-022-00415-x

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