Histone Deacetylase Inhibitors as a Therapeutic Strategy to Eliminate Neoplastic “Stromal” Cells from Giant Cell Tumors of Bone

SIMPLE SUMMARY: Giant cell tumor of bone (GCTB) is an intermediate bone neoplasm which consists of several cell populations, including the neoplastic “stromal” cells. These cells harbor a mutation in one of the histone H3.3 genes (H3F3A), and are therefore considered as the driving component of GCTB...

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Detalles Bibliográficos
Autores principales: Venneker, Sanne, van Eenige, Robin, Kruisselbrink, Alwine B., Palubeckaitė, Ieva, Taliento, Alice E., Briaire-de Bruijn, Inge H., Hogendoorn, Pancras C. W., van de Sande, Michiel A. J., Gelderblom, Hans, Mei, Hailiang, Bovée, Judith V. M. G., Szuhai, Karoly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563449/
https://www.ncbi.nlm.nih.gov/pubmed/36230631
http://dx.doi.org/10.3390/cancers14194708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563449/
https://www.ncbi.nlm.nih.gov/pubmed/36230631
http://dx.doi.org/10.3390/cancers14194708

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