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PARP1-MGMT complex underpins pathway crosstalk in O(6)-methylguanine repair
DNA lesions induced by alkylating agents are repaired by two canonical mechanisms, base excision repair dependent on poly(ADP) ribose polymerase 1 (PARP1) and the other mediated by O(6)-methylguanine (O(6)meG)-DNA methyltransferase (MGMT) in a single-step catalysis of alkyl-group removal. O(6)meG is...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563463/ https://www.ncbi.nlm.nih.gov/pubmed/36242092 http://dx.doi.org/10.1186/s13045-022-01367-4 |