Cargando…

Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation

BACKGROUND: Ongoing differentiation processes characterize the mammary gland during sexual development and reproduction. In contrast, defective remodelling is assumed to be causal for breast tumorigenesis. We have shown recently that the myocardin-related transcription factor A (MRTF-A) is essential...

Descripción completa

Detalles Bibliográficos
Autores principales:	Melcher, Marie-Luise, Block, Ines, Kropf, Karolin, Singh, Anurag Kumar, Posern, Guido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563482/ https://www.ncbi.nlm.nih.gov/pubmed/36229824 http://dx.doi.org/10.1186/s12964-022-00977-2

Ejemplares similares

Tightly controlled MRTF-A activity regulates epithelial differentiation during formation of mammary acini
por: Seifert, Anja, et al.
Publicado: (2017)

Gene regulation and deregulation by MAL/MRTF coactivators
por: Posern, G
Publicado: (2009)

MRTF-A gain-of-function in mice impairs homeostatic renewal of the intestinal epithelium
por: Singh, Anurag Kumar, et al.
Publicado: (2023)

Post-transcriptional regulation of MRTF-A by miRNAs during myogenic differentiation of myoblasts
por: Holstein, Ingo, et al.
Publicado: (2020)

Regulation of MRTF-A by JMY via a nucleation-independent mechanism
por: Kluge, Franziska, et al.
Publicado: (2018)

Lamina-associated polypeptide 2α is required for intranuclear MRTF-A activity
por: Sidorenko, Ekaterina, et al.
Publicado: (2022)

Epithelial Protein Lost in Neoplasm α (Eplin-α) is transcriptionally regulated by G-actin and MAL/MRTF coactivators
por: Leitner, Laura, et al.
Publicado: (2010)

MRTF-A controls myofibroblastic differentiation of human multipotent stromal cells and their tumour-supporting function in xenograft models
por: Werner, Sara, et al.
Publicado: (2019)

Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation
por: Sequeira, Sharon J., et al.
Publicado: (2007)

Interplay of cell–cell contacts and RhoA/MRTF‐A signaling regulates cardiomyocyte identity
por: Dorn, Tatjana, et al.
Publicado: (2018)

Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis
por: Görtzen, Jan, et al.
Publicado: (2015)

Interplay of Matrix Stiffness and Protein Tethering in Stem Cell Differentiation
por: Wen, Jessica H., et al.
Publicado: (2014)

The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis
por: Liu, Yingying, et al.
Publicado: (2010)

Unraveling the Determinants of Protrusion Formation
por: Varghese, Mita, et al.
Publicado: (2012)

Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations
por: Le Dour, Caroline, et al.
Publicado: (2022)

MRTF: Basic Biology and Role in Kidney Disease
por: Miranda, Maria Zena, et al.
Publicado: (2021)

An Interplay Between MRTF-A and the Histone Acetyltransferase TIP60 Mediates Hypoxia-Reoxygenation Induced iNOS Transcription in Macrophages
por: Yang, Yuyu, et al.
Publicado: (2020)

Corrigendum: An Interplay Between MRTF-A and the Histone Acetyltransferase TIP60 Mediates Hypoxia-Reoxygenation Induced iNOS Transcription in Macrophages
por: Yang, Yuyu, et al.
Publicado: (2021)

Corrigendum: An Interplay Between MRTF-A and the Histone Acetyltransferase TIP60 Mediates Hypoxia-Reoxygenation Induced iNOS Transcription in Macrophages
por: Yang, Yuyu, et al.
Publicado: (2021)

The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
por: Moretti, Leandro, et al.
Publicado: (2021)

Actin-Based Cell Protrusion in a 3D Matrix
por: Caswell, Patrick T., et al.
Publicado: (2018)

Cancer cell migration on elongate protrusions of fibroblasts in collagen matrix
por: Miyazaki, Kaoru, et al.
Publicado: (2019)

Matrix Metalloproteinases Regulate the Formation of Dendritic Spine Head Protrusions during Chemically Induced Long-Term Potentiation
por: Szepesi, Zsuzsanna, et al.
Publicado: (2013)

Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility
por: Stowers, Ryan S., et al.
Publicado: (2019)

Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis
por: Yu-Wai-Man, Cynthia, et al.
Publicado: (2017)

Profibrotic epithelial phenotype: a central role for MRTF and TAZ
por: Bialik, Janne Folke, et al.
Publicado: (2019)

MRTF specifies a muscle-like contractile module in Porifera
por: Colgren, J., et al.
Publicado: (2022)

Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner
por: Debnath, Jayanta, et al.
Publicado: (2003)

Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling
por: Murtagh, Janice, et al.
Publicado: (2004)

Loss of the BRCA1-Interacting Helicase BRIP1 Results in Abnormal Mammary Acinar Morphogenesis
por: Daino, Kazuhiro, et al.
Publicado: (2013)

miRNA mediated downregulation of cyclase-associated protein 1 (CAP1) is required for myoblast fusion
por: Singh, Anurag Kumar, et al.
Publicado: (2022)

A computational modeling of invadopodia protrusion into an extracellular matrix fiber network
por: Kim, Min-Cheol, et al.
Publicado: (2022)

In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness
por: Wormsbaecher, Clarissa, et al.
Publicado: (2020)

Interplay among cell migration, shaping, and traction force on a matrix with cell-scale stiffness heterogeneity
por: Ebata, Hiroyuki, et al.
Publicado: (2022)

Traveling and standing waves mediate pattern formation in cellular protrusions
por: Bhattacharya, Sayak, et al.
Publicado: (2020)

MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells
por: Liu, Chen-Ying, et al.
Publicado: (2016)

MRTF-A can activate Nrf2 to increase the resistance to doxorubicin
por: Xu, Yao, et al.
Publicado: (2016)

Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway
por: Morimatsu, Maho, et al.
Publicado: (2020)

Regulation of Dendritic Synaptic Morphology and Transcription by the SRF Cofactor MKL/MRTF
por: Tabuchi, Akiko, et al.
Publicado: (2021)

Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions
por: Lee, Meng-Horng, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_i41tefrf34d2d9ei3fphjkie0d