Mutant C. elegans p53 Together with Gain-of-Function GLP-1/Notch Decreases UVC-Damage-Induced Germline Cell Death but Increases PARP Inhibitor-Induced Germline Cell Death

SIMPLE SUMMARY: The tumor suppressor gene TP53 is conserved from nematode to human. In humans the TP53 gene is found mutated in a majority of cancers and therefore, the p53-induced cell death pathway is dysfunctional. As such, it is of the utmost importance to determine mechanisms and models to test...

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Detalles Bibliográficos
Autores principales: Canar, Jorge, Manandhar-Sasaki, Prima, Bargonetti, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563635/
https://www.ncbi.nlm.nih.gov/pubmed/36230851
http://dx.doi.org/10.3390/cancers14194929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563635/
https://www.ncbi.nlm.nih.gov/pubmed/36230851
http://dx.doi.org/10.3390/cancers14194929

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