Development of a High-Affinity Antibody against the Tumor-Specific and Hyperactive 611-p95HER2 Isoform

SIMPLE SUMMARY: In the present study, we addressed the unmet need for a molecular antibody (mAb) with high affinity and specificity against a truncated hyperactive isoform of human epidermal growth factor receptor 2 (HER2), called 611-carboxy terminal fragment (CTF)-p95HER2. Patients with p95HER2+ b...

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Detalles Bibliográficos
Autores principales: Dorraji, Esmaeil, Borgen, Elin, Segura-Peña, Dario, Rawat, Puneet, Smorodina, Eva, Dunn, Claire, Greiff, Victor, Sekulić, Nikolina, Russnes, Hege, Kyte, Jon Amund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563779/
https://www.ncbi.nlm.nih.gov/pubmed/36230782
http://dx.doi.org/10.3390/cancers14194859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563779/
https://www.ncbi.nlm.nih.gov/pubmed/36230782
http://dx.doi.org/10.3390/cancers14194859

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