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Active human full-length CDKL5 produced in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125

BACKGROUND: A significant fraction of the human proteome is still inaccessible to in vitro studies since the recombinant production of several proteins failed in conventional cell factories. Eukaryotic protein kinases are difficult-to-express in heterologous hosts due to folding issues both related...

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Detalles Bibliográficos
Autores principales: Colarusso, Andrea, Lauro, Concetta, Calvanese, Marzia, Parrilli, Ermenegilda, Tutino, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563788/
https://www.ncbi.nlm.nih.gov/pubmed/36242022
http://dx.doi.org/10.1186/s12934-022-01939-6