Targeting E2F Sensitizes Prostate Cancer Cells to Drug-Induced Replication Stress by Promoting Unscheduled CDK1 Activity

SIMPLE SUMMARY: E2F1 and E2F2 are highly expressed in many cancer types, but their contribution to malignancy is not well understood. Here we aimed to define the impact of E2F1/E2F2 deregulation in prostate cancer. We show that inhibition of E2F sensitizes prostate cancer cells to drug-induced repli...

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Detalles Bibliográficos
Autores principales: Hamidi, Mohaddase, Eriz, Ainhoa, Mitxelena, Jone, Fernandez-Ares, Larraitz, Aurrekoetxea, Igor, Aspichueta, Patricia, Iglesias-Ara, Ainhoa, Zubiaga, Ana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564059/
https://www.ncbi.nlm.nih.gov/pubmed/36230876
http://dx.doi.org/10.3390/cancers14194952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564059/
https://www.ncbi.nlm.nih.gov/pubmed/36230876
http://dx.doi.org/10.3390/cancers14194952

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