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Biogenesis of telomerase RNA from a protein-coding mRNA precursor

Telomerase is a eukaryotic ribonucleoprotein (RNP) enzyme that adds DNA repeats onto chromosome ends to maintain genomic stability and confer cellular immortality in cancer and stem cells. The telomerase RNA (TER) component is essential for telomerase catalytic activity and provides the template for...

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Detalles Bibliográficos
Autores principales: Logeswaran, Dhenugen, Li, Yang, Akhter, Khadiza, Podlevsky, Joshua D., Olson, Tamara L., Forsberg, Katherine, Chen, Julian J.-L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564094/
https://www.ncbi.nlm.nih.gov/pubmed/36197996
http://dx.doi.org/10.1073/pnas.2204636119