Relevance of Abnormal KCNN1 Expression and Osmotic Hypersensitivity in Ewing Sarcoma

SIMPLE SUMMARY: The main oncogene in Ewing sarcoma directly drives a high expression of a previously unknown variant KCNN1 (encoding the K(Ca)2.1 channel) that we also verified in samples from >200 patients. Yet, we found that the channel is not functional and does not modulate Ewing sarcoma cell...

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Detalles Bibliográficos
Autores principales: Fuest, Sebastian, Post, Christoph, Balbach, Sebastian T., Jabar, Susanne, Neumann, Ilka, Schimmelpfennig, Sandra, Sargin, Sarah, Nass, Elke, Budde, Thomas, Kailayangiri, Sareetha, Altvater, Bianca, Ranft, Andreas, Hartmann, Wolfgang, Dirksen, Uta, Rössig, Claudia, Schwab, Albrecht, Pethő, Zoltán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564116/
https://www.ncbi.nlm.nih.gov/pubmed/36230742
http://dx.doi.org/10.3390/cancers14194819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564116/
https://www.ncbi.nlm.nih.gov/pubmed/36230742
http://dx.doi.org/10.3390/cancers14194819

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