Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs

Human alpha-1-antitrypsin (AAT) encoded by the SERPINA1 gene, is an acute phase glycoprotein that regulates inflammatory responses via both protease inhibitory and non-inhibitory activities. We previously reported that AAT controls ATP-induced IL-1β release from human mononuclear cells by stimulatin...

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Detalles Bibliográficos
Autores principales: Janciauskiene, Sabina, Tumpara, Srinu, Schebb, Nils Helge, Buettner, Falk F. R., Mainka, Malwina, Sivaraman, Kokilavani, Immenschuh, Stephan, Grau, Veronika, Welte, Tobias, Olejnicka, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564231/
https://www.ncbi.nlm.nih.gov/pubmed/36249781
http://dx.doi.org/10.3389/fphar.2022.995869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564231/
https://www.ncbi.nlm.nih.gov/pubmed/36249781
http://dx.doi.org/10.3389/fphar.2022.995869

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