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Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling

Recurrent seizure is a common comorbidity in early-stage Alzheimer’s disease (AD) and may contribute to AD pathogenesis and cognitive decline. Similarly, many mouse models of Alzheimer’s disease that overproduce amyloid beta are prone to epileptiform seizures that may result in early sudden death. W...

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Detalles Bibliográficos
Autores principales: Huang, Youtong, Lemke, Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564325/
https://www.ncbi.nlm.nih.gov/pubmed/36191221
http://dx.doi.org/10.1073/pnas.2204306119