WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia

In cystic fibrosis (CF), reduced HCO(3)(−) secretion acidifies the airway surface liquid (ASL), and the acidic pH disrupts host defenses. Thus, understanding the control of ASL pH (pH(ASL)) in CF may help identify novel targets and facilitate therapeutic development. In diverse epithelia, the WNK (w...

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Detalles Bibliográficos
Autores principales: Rehman, Tayyab, Karp, Philip H., Thurman, Andrew L., Mather, Steven E., Jain, Akansha, Cooney, Ashley L., Sinn, Patrick L., Pezzulo, Alejandro A., Duffey, Michael E., Welsh, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Thoracic Society 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564924/
https://www.ncbi.nlm.nih.gov/pubmed/35849656
http://dx.doi.org/10.1165/rcmb.2022-0172OC

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564924/
https://www.ncbi.nlm.nih.gov/pubmed/35849656
http://dx.doi.org/10.1165/rcmb.2022-0172OC

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