Hyper-active RAS/MAPK introduces cancer-specific mitotic vulnerabilities

Aneuploidy, the incorrect number of whole chromosomes, is a common feature of tumors that contributes to their initiation and evolution. Preventing aneuploidy requires properly functioning kinetochores, which are large protein complexes assembled on centromeric DNA that link mitotic chromosomes to d...

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Detalles Bibliográficos
Autores principales: Herman, Jacob A., Romain, Romario R., Hoellerbauer, Pia, Shirnekhi, Hazheen K., King, David C., DeLuca, Keith F., Osborne Nishimura, Erin, Paddison, Patrick J., DeLuca, Jennifer G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565228/
https://www.ncbi.nlm.nih.gov/pubmed/36191188
http://dx.doi.org/10.1073/pnas.2208255119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565228/
https://www.ncbi.nlm.nih.gov/pubmed/36191188
http://dx.doi.org/10.1073/pnas.2208255119

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