Cargando…
Hyper-active RAS/MAPK introduces cancer-specific mitotic vulnerabilities
Aneuploidy, the incorrect number of whole chromosomes, is a common feature of tumors that contributes to their initiation and evolution. Preventing aneuploidy requires properly functioning kinetochores, which are large protein complexes assembled on centromeric DNA that link mitotic chromosomes to d...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565228/ https://www.ncbi.nlm.nih.gov/pubmed/36191188 http://dx.doi.org/10.1073/pnas.2208255119 |