Evolution avoids a pathological stabilizing interaction in the immune protein S100A9

Stability constrains evolution. While much is known about constraints on destabilizing mutations, less is known about the constraints on stabilizing mutations. We recently identified a mutation in the innate immune protein S100A9 that provides insight into such constraints. When introduced into huma...

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Detalles Bibliográficos
Autores principales: Harman, Joseph L., Reardon, Patrick N., Costello, Shawn M., Warren, Gus D., Phillips, Sophia R., Connor, Patrick J., Marqusee, Susan, Harms, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565474/
https://www.ncbi.nlm.nih.gov/pubmed/36194634
http://dx.doi.org/10.1073/pnas.2208029119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565474/
https://www.ncbi.nlm.nih.gov/pubmed/36194634
http://dx.doi.org/10.1073/pnas.2208029119

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