Cargando…
Evolution avoids a pathological stabilizing interaction in the immune protein S100A9
Stability constrains evolution. While much is known about constraints on destabilizing mutations, less is known about the constraints on stabilizing mutations. We recently identified a mutation in the innate immune protein S100A9 that provides insight into such constraints. When introduced into huma...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565474/ https://www.ncbi.nlm.nih.gov/pubmed/36194634 http://dx.doi.org/10.1073/pnas.2208029119 |