Ensemble-function relationships to dissect mechanisms of enzyme catalysis

Decades of structure-function studies have established our current extensive understanding of enzymes. However, traditional structural models are snapshots of broader conformational ensembles of interchanging states. We demonstrate the need for conformational ensembles to understand function, using...

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Detalles Bibliográficos
Autores principales: Yabukarski, Filip, Doukov, Tzanko, Pinney, Margaux M., Biel, Justin T., Fraser, James S., Herschlag, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565801/
https://www.ncbi.nlm.nih.gov/pubmed/36240280
http://dx.doi.org/10.1126/sciadv.abn7738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565801/
https://www.ncbi.nlm.nih.gov/pubmed/36240280
http://dx.doi.org/10.1126/sciadv.abn7738

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