Development of a self-replicating plasmid for non-toxic expression of CRISPR-repressors to study schizophrenia-risk genes

INTRODUCTION: Genome-wide association studies revealed that polymorphisms located within non-coding regions significantly contribute to the genetic architecture of schizophrenia. Such regions may affect the expression of tens and hundreds of neuronal genes. Epigenetic CRISPR editors help to elucidat...

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Detalles Bibliográficos
Autores principales: Abashkin, D., Kurishev, A., Karpov, D., Golimbet, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566823/
http://dx.doi.org/10.1192/j.eurpsy.2022.408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566823/
http://dx.doi.org/10.1192/j.eurpsy.2022.408

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